Browsing by Author "Romo, Daniel"
Now showing items 1-20 of 62
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Zhou, Min (Texas A&M University, 2005-02-17)Isolated from marine sponges, many bromopyrrole alkaloids have become natural products of intense scientific interest. The oroidin-derived class of dimeric bromopyrrole alkaloids that include ageliferin, bromoageliferin, ...
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Romo, Daniel; Hull, Ken; Zhu, Mingzhao; Robles, Omar (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2019-09-10)Pateamine A derivatives and pharmaceutical compositions that include the derivatives. The pateamine A derivatives are α-amino pateamine A derivatives that lack the C5-methyl group of pateamine A.
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Romo, Daniel; Hull, Ken; Zhu, Mingzhao; Robles, Omar (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2020-12-22)Pateamine A derivatives and pharmaceutical compositions that include the derivatives. The pateamine A derivatives are .alpha.-amino pateamine A derivatives that lack the C5-methyl group of pateamine A
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Romo, Daniel; Liu, Jun; Choi, Nam Song; Shi, Zonggao; Low, Woon-kai; Dang, Yongjun; Schneider-poetsch, Tilman (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2010-06-15)Provided herein are compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl ...
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Morris, Kay A. (2011-10-21)Natural products continue to inspire synthetic chemists to develop novel methodologies to provide efficient and expedient syntheses of the target molecules. Haterumalide NA aroused our interest and prompted development of ...
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Romo, Daniel; Cho, Sung Wook; Smith, Jeffrey W.; Richardson, Robyn D. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2012-02-21)Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, ...
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Romo, Daniel; Hull, Ken; Zhu, Mingzhao; Robles, Omar (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2021-01-12)Pateamine A derivatives, pharmaceutical compositions that include the derivatives, and methods for treating chronic lymphocytic leukemia using the derivatives.
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Smith, Jeffrey W.; Romo, Daniel; Ma, Gil; Zancanella, Manuel (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2012-09-04)The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof: wherein R is an alkyl group, and R1 comprises at least one moiety selected from a group ...
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Liu, Gang (2012-02-14)β-Lactones are a class of structurally unique compounds. The versatile reactivity patterns offered by β-lactones have enable chemists to utilize them as powerful synthetic vehicles in complex molecule synthesis. ...
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Joseph, Sonia (2014-06-12)Tuberculosis is one of the leading causes of death due to infectious disease. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular parasite with a slow regeneration rate. Though there is a decline ...
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Reyes, Jeremy Chris Punzalan (2013-11-08)Numerous marine-derived pyrrole 2-aminoimidazole alkaloids (P-2-AIs), including the highly potent antitumor natural product agelastatin A, are presumed to be derived from the simple precursor oroidin and ...
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Sanchez, Richard P., Jr (2010-01-14)Stereoselective carbon?carbon bond formation is one of the most important types of bond construction in organic chemistry. A mild and acid free catalyst system for the hydrovinylation reaction utilizing a cationic, ruthenium ...
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McFarlin, Rae (2013-05-02)The development of methods for site-selective derivatization of natural products to enable simultaneous arming and structure activity relationship (SAR) studies has shown great potential for the synthesis of pharmaceutical ...
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Park, Chihyo (Texas A&M University, 2007-04-25)The solid phase combinatorial method is an excellent tool for the modulation of protein-protein interactions through focused library generations. Nucleophilic aromatic substitution reactions with an iodinated template on ...
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Sepulveda Camarena, Diana (2014-12-12)Non-covalent interactions (NCIs) play vital roles in many areas of chemistry and materials science. Although there has been a great deal of progress understanding the nature of non-covalent interactions in recent years, ...
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Romo, Daniel; Henry-riyad, Huda; Lee, Changsuk; Nguyen, Henry; Purohit, Vikram C.; Oh, Seongho (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2012-01-03)The present invention provides a concise synthetic method for generating lactam-fused beta-lactones that feature, in some embodiments, a tertiary fused carbinol, quaternary carbons, and a reactive beta-lactone moiety ...
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Yau, Wai-Lok; Blisnick, Thierry; Taly, Jean-François; Helmer-Citterich, Manuela; Schiene-Fischer, Cordelia; Leclercq, Olivier; Li, Jing; Schmidt-Arras, Dirk; Morales, Miguel A.; Notredame, Cedric; Romo, Daniel; Bastin, Philippe; Späth, Gerald F.; Kelly, Ben L. (PLoS Neglected Tropical Diseases, 2010)
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Zhang, Fuwu (2015-08-01)The development of nanoscale drug delivery systems is a rapidly growing field within the realm of nanomedicine, as it has the potential to improve therapeutic efficacy and minimize side effects of various drugs. This ...
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Wu, Liangxing (2010-10-12)New methodologies for the efficient syntheses of 4,4-difluoro-4-bora-3a,4adiaza- s-indacenes (BODIPYs) and rosamines were developed. A serendipitous discovery led to a new reaction which afforded BODIPYs in high yields. ...
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Han, Junyan (2012-02-14)A xanthene-BODIPY cassette is used as a ratiometric intracellular pH reporter for imaging protein-dye conjugates in living cells. A model was hypothesized to explain the pH-dependent energy transfer efficiencies from the ...